Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

Heat shock proteins (Hsps) are a large family of molecular chaperones that are well-known
for their roles in protein maturation, re-folding and degradation. While some Hsps are …

ABSTRACT Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …

The heat shock response was originally characterized as the induction of a set of major heat
shock proteins encoded by heat shock genes. Because heat shock proteins act as molecular …

The heat shock response is a defense reaction activated by proteotoxic damage induced by
physiological or environmental stress. Cells respond to the proteotoxic damage by elevated …

Heat shock factors (HSFs) are the master regulators of transcription under protein-damaging
conditions, acting in an environment where the overall transcription is silenced. We …

Blood-tumor barrier (BTB) limits the delivery of chemotherapeutic agent to brain tumor
tissues. Long non-coding RNAs (lncRNAs) have been shown to play critical regulatory roles …

Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response
(HSR) and is essential for stress resilience. HSF is also required for metazoan development; …

Organisms must be able to sense and respond rapidly to changes in their environment in
order to maintain homeostasis and survive. Induction of heat shock proteins (Hsps) is a …