Drug delivery systems, CNS protection, and the blood brain barrier

RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …

Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications

CV Pardeshi, RV Kothawade, AR Markad… - Carbohydrate …, 2023 - Elsevier
Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that
contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with …

Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an …

W Yi-Bin, L Xiang, Y Bing, Z Qi, J Fei-Tong… - Cell Death & …, 2022 - nature.com
Neuroinflammation occurs early in Alzheimer's disease (AD). The initial stage of AD is
related to glial dysfunction, which contributes to impairment of Aβ clearance and disruption …

Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing

J Conceição, X Farto-Vaamonde, A Goyanes… - Carbohydrate …, 2019 - Elsevier
This work aimed to explore for the first time the use of cyclodextrins to prepare printlets of
poorly soluble drugs, such as carbamazepine, which require fine dose adjustment and rapid …

Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes

J Azzi, A Jraij, L Auezova, S Fourmentin… - Food …, 2018 - Elsevier
The low solubility, poor bioavailability, and low chemical stability of quercetin (Quer) are the
main drawbacks that limit its use as a food nutraceutical. In this study, the encapsulation in …

A supramolecular thermosensitive gel of ketoconazole for ocular applications: In silico, in vitro, and ex vivo studies

P Chaudhari, R Naik, LS Mallela, S Roy… - International Journal of …, 2022 - Elsevier
The incidence of corneal fungal infections continues to be a growing concern worldwide.
Ocular delivery of anti-fungal drugs is challenging due to the anatomical and physiological …

Enhanced solubility, stability, permeation and anti-cancer efficacy of Celastrol-β-cyclodextrin inclusion complex

SK Shukla, A Chan, V Parvathaneni… - Journal of Molecular …, 2020 - Elsevier
Celastrol (Cela), a pentacyclic triterpenoid, has been explored widely due to its broad
therapeutic activity such as antioxidant, chemotherapeutic, neuroprotective etc. However …

Inclusion complex of erlotinib with sulfobutyl ether-β-cyclodextrin: Preparation, characterization, in silico, in vitro and in vivo evaluation

N Devasari, CP Dora, C Singh, SR Paidi, V Kumar… - Carbohydrate …, 2015 - Elsevier
The aim of the study was to investigate the impact of erlotinib sulfobutyl ether beta-
cyclodextrin complex (ERL-SBE-β-CD) on ERL dissolution rate and oral bioavailability …

Cyclodextrins, blood–brain barrier, and treatment of neurological diseases

M Vecsernyés, F Fenyvesi, I Bácskay, MA Deli… - Archives of medical …, 2014 - Elsevier
Biological barriers are the main defense systems of the homeostasis of the organism and
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …

Molecular dynamics simulations and applications in computational toxicology and nanotoxicology

C Selvaraj, S Sakkiah, W Tong, H Hong - Food and Chemical Toxicology, 2018 - Elsevier
Nanotoxicology studies toxicity of nanomaterials and has been widely applied in biomedical
researches to explore toxicity of various biological systems. Investigating biological systems …