Polyamines are small polycations that are well conserved in all the living organisms except
Archae, Methanobacteriales and Halobacteriales. The most common polyamines are …

Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It
has provided researchers with a platform to combine powerful biochemical, statistical …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

Background The post-genomic era of malaria research provided unprecedented insights
into the biology of Plasmodium parasites. Due to the large evolutionary distance to model …

High-throughput phenotypic screening of chemical libraries has resulted in the identification
of thousands of compounds with potent antimalarial activity, although in most cases, the …

A non-targeted metabolomics-based approach is presented that enables the study of
pathways in response to drug action with the aim of defining the mode of action of …

Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

New drugs are urgently needed for the treatment of tropical and subtropical parasitic
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …

Polyamines are polycationic organic amines that are required for all eukaryotic life,
exemplified by the polyamine spermidine, which plays an essential role in translation. They …

Alphaviruses are arthropod-borne, positive-stranded RNA viruses capable of causing
severe disease with high morbidity. Chikungunya virus (CHIKV) is an alphavirus that causes …