The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
Inflammation in Parkinson's disease: mechanisms and therapeutic implications
M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease
C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …
Enteric glial biology, intercellular signalling and roles in gastrointestinal disease
L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …
many functions normally attributed to enteric neurons involve interactions with enteric glial …
Parkinson disease and the immune system—associations, mechanisms and therapeutics
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options
Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
Parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of
midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates …
midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates …
Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management
T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
Fecal microbiota transplantation in neurological disorders
KEW Vendrik, RE Ooijevaar, PRC De Jong… - Frontiers in cellular …, 2020 - frontiersin.org
Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease
Background Previous studies have reported that gut microbiota, permeability, short-chain
fatty acids (SCFAs), and inflammation are altered in Parkinson's disease (PD), but how these …
fatty acids (SCFAs), and inflammation are altered in Parkinson's disease (PD), but how these …