Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …

Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

Prolonged interferon (IFN) signaling in cancer cells can promote resistance to immune
checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to …

INTRODUCTION Tissue stem cells respond to and integrate environmental cues to
determine their fate and function. Injury induces radical changes in the microenvironment …

Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …

During development, progenitors simultaneously activate one lineage while silencing
another, a feature highly regulated in adult stem cells but derailed in cancers. Equipped to …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

The epithelial tissues that line our body, such as the skin and gut, have remarkable
regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier …

Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded
in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show …