The cancer drug discovery field has placed much emphasis on the identification of novel
and cancer-specific molecular targets. A rich source of such targets for the design of novel …

The ubiquitin–proteasome system is a major pathway for protein degradation, so that
proteasome is now considered as an important target for drug discovery. Bortezomib, the …

Apoptosis and autophagic cell deaths are programmed cell deaths and they play essential
roles in cell survival, growth and development and tumorigenesis. The huge increase of …

Despite a decrease in incidence over past decades, gastric cancer remains a major global
health problem. In the more recent period, survival has shown only minor improvement …

A major impediment to the effective treatment of cancer is the molecular heterogeneity of the
disease, which is also reflected in an equally diverse pattern of clinical responses to therapy …

Abstract Learning Objectives After completing this course, the reader will be able to: Identify
the subset of advanced gastric cancer patients who might benefit from approved anti-HER2 …

Background Survivin is known playing a role in drug resistance. However, its role in
bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are …

Background: Gastric cancer (GC) is a multifactorial progressive disease with high mortality
and heterogeneous prognosis. Effective prognostic biomarkers for GC were critically …

Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer
do as well with chemotherapy as their younger counterparts was investigated in this pooled …

Purpose The transcription factor nuclear factor-kB (NFkB) is implicated in gastric cancer
carcinogenesis and survival, and its inhibition by proteosome inhibition is associated with …