Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Y Kuchitsu, K Mukai, R Uematsu, Y Takaada… - Nature Cell …, 2023 - nature.com
Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER)
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
PI4P/phosphatidylserine countertransport at ORP5-and ORP8-mediated ER–plasma membrane contacts
Lipid transfer between cell membrane bilayers at contacts between the endoplasmic
reticulum (ER) and other membranes help to maintain membrane lipid homeostasis. We …
reticulum (ER) and other membranes help to maintain membrane lipid homeostasis. We …
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
JE Vance, G Tasseva - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …
Phosphatidylserine in the brain: metabolism and function
HY Kim, BX Huang, AA Spector - Progress in lipid research, 2014 - Elsevier
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
Cellular membranes are composed of numerous kinds of glycerophospholipids with different
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …
The receptor kinase FERONIA regulates phosphatidylserine localization at the cell surface to modulate ROP signaling
M Smokvarska, V Bayle, L Maneta-Peyret… - Science …, 2023 - science.org
Cells maintain a constant dialog between the extracellular matrix and their plasma
membrane to fine tune signal transduction processes. We found that the receptor kinase …
membrane to fine tune signal transduction processes. We found that the receptor kinase …
Membrane dynamics in autophagosome biogenesis
SR Carlsson, A Simonsen - Journal of cell science, 2015 - journals.biologists.com
Bilayered phospholipid membranes are vital to the organization of the living cell. Based on
fundamental principles of polarity, membranes create borders allowing defined spaces to be …
fundamental principles of polarity, membranes create borders allowing defined spaces to be …