[HTML][HTML] The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
Biomanufacturing human tissues via organ building blocks
The construction of human organs on demand remains a tantalizing vision to solve the
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …
A reference human induced pluripotent stem cell line for large-scale collaborative studies
CB Pantazis, A Yang, E Lara, JA McDonough… - Cell stem cell, 2022 - cell.com
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs
TD Arthur, JP Nguyen, A D'Antonio-Chronowska… - Nature …, 2024 - nature.com
Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …
hundreds of hiPSCs derived from different individuals, we show the proportions of these …
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells
F Jiang, L Wang, Y Dong, W Nie… - Proceedings of the …, 2023 - National Acad Sciences
Genetic alterations are often acquired during prolonged propagation of pluripotent stem
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
[HTML][HTML] Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q
Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications
in research and clinic. However, the mechanisms that underpin selection of variants remain …
in research and clinic. However, the mechanisms that underpin selection of variants remain …
Carnegie in 4D? Stem-cell-based models of human embryo development
B Sozen, D Conkar, JV Veenvliet - Seminars in cell & developmental …, 2022 - Elsevier
How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …
study of the processes that pattern and shape the embryo in live specimens, in toto, across …
Somatic mutations alter the differentiation outcomes of iPSC-derived neurons
P Puigdevall, J Jerber, P Danecek, S Castellano… - Cell genomics, 2023 - cell.com
The use of induced pluripotent stem cells (iPSC) as models for development and human
disease has enabled the study of otherwise inaccessible tissues. A remaining challenge in …
disease has enabled the study of otherwise inaccessible tissues. A remaining challenge in …
Pluripotent stem cell strategies for rebuilding the human brain
Neurodegenerative disorders have been extremely challenging to treat with traditional drug-
based approaches and curative therapies are lacking. Given continued progress in stem cell …
based approaches and curative therapies are lacking. Given continued progress in stem cell …