In December 2019, a new variant of SARS-CoV emerged, the so-called acute severe
respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes the new coronavirus …

Nilotinib, a second-generation tyrosine kinase inhibitor for the treatment of chronic
myelogenous leukemia (CML), inhibits Bcr-Abl tyrosine kinase activity and proliferation of …

Routes were proposed for the synthesis of new pyrimidine-derived polycyclic nitrogen
heterocycles–4-(1 H-pyrazol-1-yl)-2-(pyridin-2-yl) pyrimidines with various donor …

The unique features of ferrocene and the need for development of targeted anticancer drugs
inspired the design, synthesis and biological evaluation of ferrocenyl modified tyrosine …

Encouraged by the excellent antiplatelet properties of novel imatinib and nilotinib analogues
in our previous study and based on a fact that slight structural changes, such as the …

Background Platelets play important roles in cancer progression and metastasis, as well as
in cancer-associated thrombosis (CAT). Tyrosine kinases are implicated in several …

Osimertinib, a third generation potent and specific EGFR inhibitor is an important drug
against many forms of cancer. It was synthesized by an improved and highly efficient …

In view of potent kinase inhibitors for the treatment of myriad human disorders, we
synthesized some structurally variant amide/cyclic amide derivatives based on …

Предложены схемы синтеза новых полициклических азотистых гетероциклов на
основе производных пиримидина: 4-(1Н-пиразол-1-ил)-2-(пиридин-2-ил) пиримидинов с …

Acute Myeloid Leukaemia (AML) is a haematopoietic malignancy which comprises of
different genetic subtypes with a common hallmark of differentiation arrest. In abnormal …