Accessing p‐Hydroxycinnamic Acids: Chemical Synthesis, Biomass Recovery, or Engineered Microbial Production?

AL Flourat, J Combes, C Bailly‐Maitre‐Grand… - …, 2021 - Wiley Online Library
Abstract p‐Hydroxycinnamic acids (ie, p‐coumaric, ferulic, sinapic, and caffeic acids) are
phenolic compounds involved in the biosynthesis pathway of lignin. These naturally …

Biological valorization of lignin to flavonoids

HN Lan, RY Liu, ZH Liu, X Li, BZ Li, YJ Yuan - Biotechnology Advances, 2023 - Elsevier
Lignin is the most affluent natural aromatic biopolymer on the earth, which is the promising
renewable source for valuable products to promote the sustainability of biorefinery …

[HTML][HTML] De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Q Liu, Y Liu, G Li, O Savolainen, Y Chen… - Nature …, 2021 - nature.com
Isoflavonoids comprise a class of plant natural products with great nutraceutical,
pharmaceutical and agricultural significance. Their low abundance in nature and structural …

Remodelling metabolism for high-level resveratrol production in Yarrowia lipolytica

M Liu, C Wang, X Ren, S Gao, S Yu, J Zhou - Bioresource Technology, 2022 - Elsevier
Resveratrol is a polyphenol with numerous applications in food, pharma, and cosmetics.
Lack of precursors and low titer are the main problems hindering industrial scale resveratrol …

Construction of an l-Tyrosine Chassis in Pichia pastoris Enhances Aromatic Secondary Metabolite Production from Glycerol

R Kumokita, T Bamba, K Inokuma, T Yoshida… - ACS Synthetic …, 2022 - ACS Publications
Bioactive plant-based secondary metabolites such as stilbenoids, flavonoids, and
benzylisoquinoline alkaloids (BIAs) are produced from l-tyrosine (l-Tyr) and have a wide …

Towards the sustainable production of bulk-chemicals using biotechnology

JM Woodley - New biotechnology, 2020 - Elsevier
The design and development of new routes for the production of sustainable bulk-chemicals
requires focus on feedstock, conversion technology and downstream product recovery. This …

[HTML][HTML] Synthetic biology-driven microbial production of resveratrol: advances and perspectives

C Feng, J Chen, W Ye, K Liao, Z Wang… - … in Bioengineering and …, 2022 - frontiersin.org
Resveratrol, a bioactive natural product found in many plants, is a secondary metabolite and
has attracted much attention in the medicine and health care products fields due to its …

[HTML][HTML] Metabolic engineering of Rhodotorula toruloides for resveratrol production

M Zhang, Q Gao, Y Liu, Z Fang, Z Gong, ZK Zhao… - Microbial Cell …, 2022 - Springer
Background Resveratrol is a plant-derived phenylpropanoid with diverse biological activities
and pharmacological applications. Plant-based extraction could not satisfy ever-increasing …

[HTML][HTML] Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production

Y Zhang, M Su, Y Chen, Z Wang, J Nielsen… - Biotechnology for Biofuels …, 2023 - Springer
Background With unique physiochemical environments in subcellular organelles, there has
been growing interest in harnessing yeast organelles for bioproduct synthesis. Among these …

[HTML][HTML] Rational engineering of Kluyveromyces marxianus to create a chassis for the production of aromatic products

AS Rajkumar, JP Morrissey - Microbial Cell Factories, 2020 - Springer
Abstract Background The yeast Kluyveromyces marxianus offers unique potential for
industrial biotechnology because of useful features like rapid growth, thermotolerance and a …