Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Inflammation is a crucial component of various stress-induced responses that contributes to
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …

Endometrial cancer is one of the most common cancers of the female reproductive system.
Although surgery, radiotherapy, chemotherapy, and hormone therapy can significantly …

Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the
interorgan crosstalk network through adipokines, which cause pleiotropic effects, including …

Salvianolic acid B (SalB), a natural polyphenolic compound extracted from the herb of Salvia
miltiorrhiza, possesses antioxidant and neuroprotective properties and has been shown to …

Background There is evidence that low doses or physiological concentrations of certain
natural polyphenols enhance the activity of telomerase. However, the precise mechanism by …

Leptin is an obesity-associated adipokine that is known to regulate energy metabolism and
reproduction and to control appetite via the leptin receptor. Recent work has identified …

Abstract SIRT1, an NAD+-dependent histone/protein deacetylase, has diverse physiological
actions. Recent studies have demonstrated that SIRT1 is overexpressed in colorectal …

Nowadays, it is well-known that the deregulation of epigenetic machinery is a common
biological event leading to the development and progression of metabolic disorders …