Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

I Jurado-Martín, M Sainz-Mejías… - International journal of …, 2021 - mdpi.com
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Opportunistic pathogens in cystic fibrosis: epidemiology and pathogenesis of lung infection

AC Blanchard, VJ Waters - Journal of the Pediatric Infectious …, 2022 - academic.oup.com
Cystic fibrosis (CF) is one of the most common life-shortening genetic diseases in
Caucasians. Due to abnormal accumulation of mucus, respiratory failure caused by chronic …

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

S O'Brien, JL Fothergill - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients.
However, it is now recognised that a diverse microbial community exists in the airways …

Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis

K Tomomatsu, H Yasuba, T Ishiguro, S Imokawa… - Scientific Reports, 2023 - nature.com
Despite standard treatment with systemic corticosteroids and/or antifungal triazoles, a
substantial proportion of patients with allergic bronchopulmonary aspergillosis (ABPA) …

Role of RND efflux pumps in drug resistance of cystic fibrosis pathogens

VC Scoffone, G Trespidi, G Barbieri, S Irudal, E Perrin… - Antibiotics, 2021 - mdpi.com
Drug resistance represents a great concern among people with cystic fibrosis (CF), due to
the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug …

Pseudomonas aeruginosa in bronchiectasis: infection, inflammation, and therapies

C Vidaillac, SH Chotirmall - Expert review of respiratory medicine, 2021 - Taylor & Francis
Introduction: Bronchiectasis is a chronic endobronchial suppurative disease characterized
by irreversibly dilated bronchi damaged by repeated polymicrobial infections and …

Aspergillus fumigatus Inhibits Pseudomonas aeruginosa in Co-culture: Implications of a Mutually Antagonistic Relationship on Virulence and Inflammation in the CF …

E Reece, S Doyle, P Greally, J Renwick… - Frontiers in …, 2018 - frontiersin.org
Many cystic fibrosis (CF) airway infections are considered to be polymicrobial and microbe–
microbe interactions may play an important role in disease pathology. Pseudomonas …

Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

U Düesberg, J Wosniok, L Naehrlich, P Eschenhagen… - Scientific reports, 2020 - nature.com
Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly
caused by bacteria, eg Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is …

Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility of Pseudomonas aeruginosa

E Reece, PHA Bettio, J Renwick - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is one of the most dominant pathogens in cystic fibrosis (CF)
airway disease and contributes to significant inflammation, airway damage, and poorer …

Let's get physical: bacterial-fungal interactions and their consequences in agriculture and health

BN Steffan, N Venkatesh, NP Keller - Journal of Fungi, 2020 - mdpi.com
Fungi serve as a biological scaffold for bacterial attachment. In some specialized
interactions, the bacteria will invade the fungal host, which in turn provides protection and …