This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

Epithelial Na+ channels (ENaCs) are members of the ENaC/degenerin family of ion
channels that evolved to respond to extracellular factors. In addition to being expressed in …

Fluid shear stress is an important environmental cue that governs vascular physiology and
pathology, but the molecular mechanisms that mediate endothelial responses to flow are …

Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical
pathways and as such are involved in several disease states. Dependent on site and type of …

Abstract Introduction Piezo1 and Piezo2 are mechanosensitive membrane ion channels. We
hypothesized that Piezo proteins may play a role in transducing ultrasound-associated …

The endothelial surface is a highly flexible signaling hub which is able to sense the
hemodynamic forces of the streaming blood. The subsequent mechanosignaling is basically …

Canonical epithelial sodium channels (ENaCs) are heterotrimers formed by α, β, and γ
ENaC subunits in vertebrates and belong to the Degenerin/ENaC family of proteins. Proteins …

The Epithelial Sodium Channel (ENaC) is a key player in renal sodium homeostasis. The
expression of α β γ ENaC subunits has also been described in the endothelium and …