Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
Redox signaling in cardiac physiology and pathology
JR Burgoyne, H Mongue-Din, P Eaton… - Circulation …, 2012 - Am Heart Assoc
Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications
N Apostolova, VM Victor - Antioxidants & redox signaling, 2015 - liebertpub.com
Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …
fundamental in controlling the life and death of cells, and has been implicated in a wide …
Calcium cycling proteins and heart failure: mechanisms and therapeutics
AR Marks - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
TNF-α in the cardiovascular system: from physiology to therapy
K Urschel, I Cicha - … Journal of Interferon, Cytokine and Mediator …, 2015 - Taylor & Francis
Signaling pathways induced by the proinflammatory cytokine tumor necrosis factor alpha
(TNF-α) play a key role in the cellular responses to inflammation and injury. In the …
(TNF-α) play a key role in the cellular responses to inflammation and injury. In the …
Ryanodine receptors: physiological function and deregulation in Alzheimer disease
Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …
central player in Alzheimer disease (AD). Accordingly, different studies have reported …
Tumor necrosis factor family members and myocardial ischemia-reperfusion injury: state of the art and therapeutic implications
Ischemic heart disease is the principal cause of death worldwide and clinically manifests as
myocardial infarction (MI), stable angina, and ischemic cardiomyopathy. Myocardial …
myocardial infarction (MI), stable angina, and ischemic cardiomyopathy. Myocardial …
Role of hydrogen sulfide in ischemia‐reperfusion injury
D Wu, J Wang, H Li, M Xue, A Ji… - Oxidative medicine and …, 2015 - Wiley Online Library
Ischemia‐reperfusion (I/R) injury is one of the major causes of high morbidity, disability, and
mortality in the world. I/R injury remains a complicated and unresolved situation in clinical …
mortality in the world. I/R injury remains a complicated and unresolved situation in clinical …