Apelin, an endogenous ligand for the G protein–coupled receptor (APJ), is widely distributed
within the central nervous system and diverse organs in human and animals. Recent studies …

The G-protein-coupled receptor APJ and its endogenous ligand apelin are widely expressed
in many peripheral tissues and central nervous system, including adipose tissue, skeletal …

Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a
protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our …

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary
vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right …

Apelin is an endogenous ligand of seven‐transmembrane G protein‐coupled receptor APJ.
Apelin and APJ are distributed in various tissues, including the heart, lung, kidney, and even …

Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD).
Recent studies indicate that blood from young mice reduces age-associated pathologies …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are incurable diseases characterized by progressive loss of …

Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is expressed in a
diverse number of organs. The apelin–APJ axis helps to control the processes of …

Vascular calcification (VC) is an inducement of many cardiovascular diseases. Clinic
evidences have confirmed that diabetes was the independent risk factor for VC, and the …

AIM To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to
be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum …