The aim of the current review is to summarise the present status of physiologically based
pharmacokinetic (PBPK) modelling and its applications in drug research, and thus serve as …

During recent years there has been a surge in developing and applying physiologically
based pharmacokinetic (PBPK) models in pregnant women to better understand and predict …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

At present, regulatory assessment of systemic toxicity is almost solely carried out using
animal models. The European Commission's REACH legislation stimulates the use of …

The purpose of this article is to provide an overview and practical guide to occupational
health professionals concerning the derivation and use of dose estimates in risk assessment …

Prerequisite to understanding abnormal development is a firm grasp of normal development.
An overview of normal mammalian development is provided in this volume by Donahoe and …

In today's scientific and regulatory climates, an increased emphasis is placed on the
potential health impacts for children exposed either in utero or by nursing to drugs of abuse …

Atrazine (ATR) is a widely used chlorotriazine herbicide, a ubiquitous environmental
contaminant, and a potential developmental toxicant. To quantitatively evaluate …

The new EU legislations for chemicals (Registration, Evaluation and Authorization of
Chemicals, REACH) and cosmetics (Seventh Amendment) stimulate the acceptance of in …

Numerous experimental studies have established that only a few among the large family of
ethylene glycol ethers (EGEs) elicit toxicity on reproduction in either gender. Notable are the …