Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

C Schiano, G Benincasa, M Franzese… - Pharmacology & …, 2020 - Elsevier
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Epigenetic mechanisms of neurodegenerative diseases and acute brain injury

MJ Bertogliat, KC Morris-Blanco… - Neurochemistry …, 2020 - Elsevier
Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Circular RNA 0025984 ameliorates ischemic stroke injury and protects astrocytes through miR-143-3p/TET1/ORP150 pathway

D Zhou, Z Huang, X Zhu, T Hong, Y Zhao - Molecular neurobiology, 2021 - Springer
Abstract MiR-143-3p is aberrantly expressed in patients with ischemic stroke and associated
with ischemic brain injury. However, the underlying mechanisms are largely unknown. Here …

Epigenetic mechanisms and potential therapeutic targets in stroke

KC Morris-Blanco, AK Chokkalla… - Journal of Cerebral …, 2022 - journals.sagepub.com
Accumulating evidence indicates a central role for epigenetic modifications in the
progression of stroke pathology. These epigenetic mechanisms are involved in complex and …

Genome-wide blood DNA methylation analysis in patients with delayed cerebral ischemia after subarachnoid hemorrhage

BJ Kim, Y Kim, DH Youn, JJ Park, JK Rhim, HC Kim… - Scientific Reports, 2020 - nature.com
Little is known about the epigenetic changes associated with delayed cerebral ischemia
(DCI) pathogenesis after subarachnoid hemorrhage (SAH). Here, we investigated genome …

Extracellular mitochondrial dysfunction in cerebrospinal fluid of patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

DH Youn, BJ Kim, Y Kim, JP Jeon - Neurocritical Care, 2020 - Springer
Background Mitochondrial dysfunction is related to brain ischemic injury and neural cell
death. However, little is known about the association between mitochondrial dysfunction of …

Monitoring of delayed cerebral ischemia in patients with subarachnoid hemorrhage via near-infrared spectroscopy

JJ Park, C Kim, JP Jeon - Journal of clinical medicine, 2020 - mdpi.com
We investigated the role of near infrared spectroscopy (NIRS) in identifying delayed cerebral
ischemia (DCI) in patients with subarachnoid hemorrhage (SAH). We measured the cerebral …

Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review

M Tjerkstra, H Labib, BA Coert… - Journal of …, 2023 - journals.aboutscience.eu
Delayed cerebral ischemia (DCI) substantially contributes to disability and death in
subarachnoid hemorrhage (SAH) patients; however, its pathophysiology is incompletely …

[HTML][HTML] DNA methylation of the TPMT gene and azathioprine pharmacokinetics in children with very early onset inflammatory bowel disease

D Selvestrel, G Stocco, M Aloi, S Arrigo… - Biomedicine & …, 2023 - Elsevier
Background Thiopurine methyltransferase (TPMT) is a crucial enzyme for azathioprine
biotransformation and its activity is higher in very early onset inflammatory bowel disease …

[HTML][HTML] A preliminary study of the association between SOX17 gene variants and intracranial aneurysms using exome sequencing

JJ Park, BJ Kim, DH Youn, HJ Choi… - Journal of Korean …, 2020 - synapse.koreamed.org
Objective Conflicting results regarding SOX17 genes and the risk of intracranial aneurysms
(IA) exist in the Korean population, although significant positive correlations were noted in …