Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
Epigenetic mechanisms of neurodegenerative diseases and acute brain injury
MJ Bertogliat, KC Morris-Blanco… - Neurochemistry …, 2020 - Elsevier
Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …
Circular RNA 0025984 ameliorates ischemic stroke injury and protects astrocytes through miR-143-3p/TET1/ORP150 pathway
D Zhou, Z Huang, X Zhu, T Hong, Y Zhao - Molecular neurobiology, 2021 - Springer
Abstract MiR-143-3p is aberrantly expressed in patients with ischemic stroke and associated
with ischemic brain injury. However, the underlying mechanisms are largely unknown. Here …
with ischemic brain injury. However, the underlying mechanisms are largely unknown. Here …
Epigenetic mechanisms and potential therapeutic targets in stroke
KC Morris-Blanco, AK Chokkalla… - Journal of Cerebral …, 2022 - journals.sagepub.com
Accumulating evidence indicates a central role for epigenetic modifications in the
progression of stroke pathology. These epigenetic mechanisms are involved in complex and …
progression of stroke pathology. These epigenetic mechanisms are involved in complex and …
Genome-wide blood DNA methylation analysis in patients with delayed cerebral ischemia after subarachnoid hemorrhage
Little is known about the epigenetic changes associated with delayed cerebral ischemia
(DCI) pathogenesis after subarachnoid hemorrhage (SAH). Here, we investigated genome …
(DCI) pathogenesis after subarachnoid hemorrhage (SAH). Here, we investigated genome …
Extracellular mitochondrial dysfunction in cerebrospinal fluid of patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
DH Youn, BJ Kim, Y Kim, JP Jeon - Neurocritical Care, 2020 - Springer
Background Mitochondrial dysfunction is related to brain ischemic injury and neural cell
death. However, little is known about the association between mitochondrial dysfunction of …
death. However, little is known about the association between mitochondrial dysfunction of …
Monitoring of delayed cerebral ischemia in patients with subarachnoid hemorrhage via near-infrared spectroscopy
JJ Park, C Kim, JP Jeon - Journal of clinical medicine, 2020 - mdpi.com
We investigated the role of near infrared spectroscopy (NIRS) in identifying delayed cerebral
ischemia (DCI) in patients with subarachnoid hemorrhage (SAH). We measured the cerebral …
ischemia (DCI) in patients with subarachnoid hemorrhage (SAH). We measured the cerebral …
Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review
M Tjerkstra, H Labib, BA Coert… - Journal of …, 2023 - journals.aboutscience.eu
Delayed cerebral ischemia (DCI) substantially contributes to disability and death in
subarachnoid hemorrhage (SAH) patients; however, its pathophysiology is incompletely …
subarachnoid hemorrhage (SAH) patients; however, its pathophysiology is incompletely …
[HTML][HTML] DNA methylation of the TPMT gene and azathioprine pharmacokinetics in children with very early onset inflammatory bowel disease
D Selvestrel, G Stocco, M Aloi, S Arrigo… - Biomedicine & …, 2023 - Elsevier
Background Thiopurine methyltransferase (TPMT) is a crucial enzyme for azathioprine
biotransformation and its activity is higher in very early onset inflammatory bowel disease …
biotransformation and its activity is higher in very early onset inflammatory bowel disease …
[HTML][HTML] A preliminary study of the association between SOX17 gene variants and intracranial aneurysms using exome sequencing
JJ Park, BJ Kim, DH Youn, HJ Choi… - Journal of Korean …, 2020 - synapse.koreamed.org
Objective Conflicting results regarding SOX17 genes and the risk of intracranial aneurysms
(IA) exist in the Korean population, although significant positive correlations were noted in …
(IA) exist in the Korean population, although significant positive correlations were noted in …