SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities

A Andrades, P Peinado, JC Alvarez-Perez… - Molecular cancer, 2023 - Springer
Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

A Zhao, H Zhou, J Yang, M Li, T Niu - Signal Transduction and Targeted …, 2023 - nature.com
Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Aggressive Lymphoma after CD19 CAR T-Cell Therapy

G Kobbe, M Brüggemann, BN Baermann… - … England Journal of …, 2024 - Mass Medical Soc
The development of a fatal, clonal, autonomously proliferating CD4− CD8− chimeric antigen
receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient …

Game of clones: Diverse implications for clonal hematopoiesis in lymphoma and multiple myeloma

J Meier, JL Jensen, C Dittus, CC Coombs, S Rubinstein - Blood Reviews, 2022 - Elsevier
Clonal hematopoiesis (CH) refers to the disproportionate expansion of hematopoietic stem
cell clones and their corresponding progeny following the acquisition of somatic mutations …

The dark side of stemness–the role of hematopoietic stem cells in development of blood malignancies

J Filipek-Gorzała, P Kwiecińska, A Szade… - Frontiers in …, 2024 - frontiersin.org
Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism.
However, the high self-renewal and longevity of HSCs predispose them to accumulate …

Mature T-cell and NK-cell lymphomas: updates on molecular genetic features

NE Lewis, R Sardana, A Dogan - International Journal of Hematology, 2023 - Springer
Mature T-cell and NK-cell lymphomas are a heterogeneous group of rare and typically
aggressive neoplasms. Diagnosis and subclassification have historically relied primarily on …

Pathologic and molecular insights in nodal T-follicular helper cell lymphomas

ML Marques-Piubelli, C Amador, F Vega - Frontiers in Oncology, 2023 - frontiersin.org
T-follicular helper (TFH) cells are one of the T-cell subsets with a critical role in the
regulation of germinal center (GC) reactions. TFH cells contribute to the positive selection of …

Clonal haematopoiesis: A common progenitor for cytotoxic peripheral T‐cell lymphoma and angioimmunoblastic T‐cell lymphoma

A Vogelsberg, L Harland, V Borgmann… - British journal of …, 2024 - Wiley Online Library
Recent studies have shown that follicular helper T‐cell lymphoma of angioimmunoblastic
type (AITL), the most common nodal peripheral T‐cell lymphoma (PTCL), frequently arises in …

The emerging role of TET enzymes in the immune microenvironment at the maternal-fetal interface during decidualization and early pregnancy

M Jin, J Ji, X Chen, Y Zhou, D Wang, A Liu - Frontiers in Immunology, 2023 - frontiersin.org
A dysregulated immune microenvironment at the maternal-fetal interface in early pregnancy
may lead to early pregnancy loss, fetal growth restriction, and preeclampsia. However, major …

Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP Workshop

C Amador, JR Cook, M Czader… - American Journal of …, 2023 - academic.oup.com
Objectives Sessions 8 and 9 of the 2021 Society for Hematopathology and the European
Association for Haematopathology Workshop aimed to collect examples of …