Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology,
primarily affecting the joints, then extra-articular manifestations can occur. Due to its …

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

Rheumatoid arthritis (RA) is a chronic multifactorial disorder of autoimmune etiology with a
complex pathophysiological mechanism that is not yet fully elucidated. RA pharmacotherapy …

Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

Alopecia areata (AA) is a relapsing, chronic, immune-mediated disease characterized by
nonscarring, inflammatory hair loss that can affect any hair-bearing site. AA clinical …

Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical
manifestations of joint inflammation, bone damage and cartilage destruction, joint …

Vitiligo is a chronic autoimmune depigmenting skin disorder characterized by patches of the
skin losing functional melanocytes. Multiple combinatorial factors are involved in disease …

Rheumatoid arthritis (RA) is an autoimmune disorder that affects the joints. Various
medications successfully alleviate the symptoms of RA in clinical. Still, few therapy strategies …

Baricitinib, an oral selective Janus kinase (JAK) 1/JAK2 inhibitor, is approved as
monotherapy or in combination with methotrexate for treating adults with moderate-to-severe …