The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses

J McAlpine, A Leon‐Castillo… - The Journal of pathology, 2018 - Wiley Online Library
Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly
clear that this heterogeneity may be a function of the diversity of the underlying molecular …

[HTML][HTML] Current and emerging prognostic biomarkers in endometrial cancer

K Njoku, CE Barr, EJ Crosbie - Frontiers in Oncology, 2022 - frontiersin.org
Endometrial cancer is the most common gynaecological malignancy in high income
countries and its incidence is rising. Whilst most women with endometrial cancer are …

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

N Concin, X Matias-Guiu, I Vergote, D Cibula… - International Journal of …, 2021 - ijgc.bmj.com
A European consensus conference on endometrial carcinoma was held in 2014 to produce
multi-disciplinary evidence-based guidelines on selected questions. Given the large body of …

Cancer of the corpus uteri: 2021 update

M Koskas, F Amant, MR Mirza… - International Journal of …, 2021 - Wiley Online Library
Endometrial cancer is the most common gynecological malignancy in high‐and middle‐
income countries. Although the overall prognosis is relatively good, high‐grade endometrial …

[HTML][HTML] Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy

BG Wortman, CL Creutzberg, H Putter… - British journal of …, 2018 - nature.com
Background PORTEC-2 was a randomised trial for women with high-intermediate risk (HIR)
endometrial cancer, comparing pelvic external beam radiotherapy (EBRT) with vaginal …

[HTML][HTML] Prognostic relevance of the molecular classification in high-grade endometrial cancer for patients staged by lymphadenectomy and without adjuvant treatment

A Leon-Castillo, N Horeweg, EEM Peters, T Rutten… - Gynecologic …, 2022 - Elsevier
Introduction The clinical role of the molecular endometrial cancer (EC) classification has not
been fully explored in patients staged with lymphadenectomy or without adjuvant treatment …

Cancer of the corpus uteri

F Amant, MR Mirza, M Koskas… - International Journal of …, 2018 - Wiley Online Library
Endometrial cancer is the most common gynecological malignancy in high‐income
countries. Although the overall prognosis is relatively good, high‐grade endometrial cancers …

[HTML][HTML] Molecular-integrated risk profile to determine adjuvant radiotherapy in endometrial cancer: evaluation of the pilot phase of the PORTEC-4a trial

BG Wortman, T Bosse, RA Nout, LCHW Lutgens… - Gynecologic …, 2018 - Elsevier
Abstract Objective The Post-Operative Radiation Therapy in Endometrial Carcinoma
(PORTEC)-4a trial is a randomized trial for women with high-intermediate risk endometrial …

Treatment strategies for endometrial cancer: current practice and perspective

YC Lee, S Lheureux, AM Oza - Current Opinion in Obstetrics and …, 2017 - journals.lww.com
Our understanding of endometrial cancer has evolved through improvements in molecular
biology, allowing improved definition of target-specific therapies. The precise role and …

Molecular subtypes of clear cell carcinoma of the endometrium: opportunities for prognostic and predictive stratification

SR Kim, BT Cloutier, S Leung, D Cochrane… - Gynecologic …, 2020 - Elsevier
Objective Our aim was to characterize the pathological, molecular and clinical outcomes of
clear cell carcinoma of the endometrium (CCC). Methods CCC underwent ProMisE …