New approaches for cryptococcosis treatment

CC Spadari, F Wirth, LB Lopes, K Ishida - Microorganisms, 2020 - mdpi.com
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in
patients with HIV infection. The antifungal pharmacological treatment is limited to …

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

M Barani, M Mukhtar, A Rahdar, G Sargazi… - Molecules, 2021 - mdpi.com
The blood–brain barrier (BBB) is the protective sheath around the brain that protects the
sensitive microenvironments of the brain. However, certain pathogens, viruses, and bacteria …

Application of af4-multidetection to liraglutide in its formulation: Preserving and representing native aggregation

V Marassi, M Macis, S Giordani, L Ferrazzano… - Molecules, 2022 - mdpi.com
Aggregation is among the most critical parameters affecting the pharmacological and safety
profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost …

Selective Segregation of Thermo‐Responsive Microgels via Microfluidic Technology

A Sharma, F Rohne, D Vasquez‐Muñoz… - Small …, 2024 - Wiley Online Library
Separation of equally sized particles distinguished solely by material properties remains still
a very challenging task. Here a simple separation of differently charged, thermo‐responsive …

[HTML][HTML] Comparative studies of the uptake and internalization pathways of different lipid nano-systems intended for brain delivery

L Mihailova, D Shalabalija, A Zimmer, N Geskovski… - Pharmaceutics, 2023 - mdpi.com
Lipid nano-systems were prepared and characterized in a series of well-established in vitro
tests that could assess their interactions with the hCMEC/D3 and SH-SY5Y cell lines as a …

Sustained release matrix tablet of 100 mg losartan potassium: Formulation development and in vitro characterization

D Devi, A Ghosh, UK Mandal - Brazilian Journal of Pharmaceutical …, 2022 - SciELO Brasil
Sustained release matrix tablets of 100 mg losartan potassium HCl were fabricated with two
release retarding polymers namely HPMC K100 M and affinisol by direct compression …

Nanoparticle delivery through the BBB in central nervous system tuberculosis

A Griego, E Scarpa, V De Matteis, L Rizzello - Ibrain, 2023 - Wiley Online Library
Recent advances in Nanotechnology have revolutionized the production of materials for
biomedical applications. Nowadays, there is a plethora of nanomaterials with potential for …

Preparation and Optimization of Leuprolide Acetate Nanoparticles Using Response Surface Methodology: In Vitro and Ex Vivo Evaluation

T Pandya, A Dharamsi - ASSAY and Drug Development …, 2022 - liebertpub.com
This study aims to develop optimized leuprolide acetate (LA) nanoparticles (NPs) for
intranasal delivery in the treatment of Alzheimer's disease. Box–Behnken Design was used …

Microcrystalline Cellulose Based Adsorbent Derived from Watermelon Rind for Dye Removal

MHJ Ho, YY Lee, CVC Sia… - Journal of Advanced …, 2024 - semarakilmu.com.my
This study investigated the potential of watermelon rind derived microcrystalline cellulose
(MCC) for the removal of methylene blue dye from aqueous solutions. The objectives were …

Towards Data-driven Development of Advanced Drug Formulations Leveraging Machine Learning and Experimental Automation

Z Bao - 2024 - search.proquest.com
The majority of new drugs fail during clinical trials, primarily due to ineffective performance,
unacceptable side effects, and poor drug-like properties. Typically, many of these issues can …