Simulation studies of amyloidogenic polypeptides and their aggregates

IM Ilie, A Caflisch - Chemical reviews, 2019 - ACS Publications
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …

Enhanced optical asymmetry in supramolecular chiroplasmonic assemblies with long-range order

J Lu, Y Xue, K Bernardino, NN Zhang, WR Gomes… - Science, 2021 - science.org
Chiral assemblies of plasmonic nanoparticles are known for strong circular dichroism but not
for high optical asymmetry, which is limited by the unfavorable combination of electrical and …

Biomolecular Material Recognition in Two Dimensions: Peptide Binding to Graphene, h-BN, and MoS2 Nanosheets as Unique Bioconjugates

TR Walsh, MR Knecht - Bioconjugate chemistry, 2019 - ACS Publications
Two-dimensional nanosheet-based materials such as graphene, hexagonal boron nitride,
and MoS2 represent intriguing structures for a variety of biological applications ranging from …

Chymosin pretreatment accelerated papain catalysed hydrolysis for decreasing casein antigenicity by exposing the cleavage site at tyrosine residues

J Zeng, J Zou, J Zhao, K Lin, L Zhang, H Yi, P Gong - Food Chemistry, 2023 - Elsevier
Cow milk protein allergy (CMPA) induced by casein poses major health challenges that
hinders the consumption of milk-based formulas. In this study, a novel sequential enzymatic …

[HTML][HTML] Molecular dynamics simulation studies on the aggregation of amyloid-β peptides and their disaggregation by ultrasonic wave and infrared laser irradiation

H Okumura, SG Itoh - Molecules, 2022 - mdpi.com
Alzheimer's disease is understood to be caused by amyloid fibrils and oligomers formed by
aggregated amyloid-β (Aβ) peptides. This review article presents molecular dynamics (MD) …

Interactions between Lipid Vesicle Membranes and Single Amino Acid Fibrils: Probable Origin of Specific Neurological Disorders

S Nandi, N Sarkar - Langmuir, 2024 - ACS Publications
Amyloid fibrils are known to be responsible for several neurological disorders, like
Alzheimer's disease (AD), Parkinson's disease (PD), etc. For decades, mostly proteins and …

Biofunctionalization of graphene and its two-dimensional analogues and synthesis of biomimetic materials: A review

S Di, Y Qian, L Wang, Z Li - Journal of Materials Science, 2022 - Springer
Abstract Two-dimensional (2D) materials have become a “rising star” in the eyes of scientists
because of their designability, manipulability, and ease of functionalization. When the 2D …

High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization

M Kojima, S Abe, T Furuta, K Hirata… - Proceedings of the …, 2024 - National Acad Sciences
Intrinsically disordered proteins (IDPs) play a crucial role in various biological phenomena,
dynamically changing their conformations in response to external environmental cues. To …

Nanobiotechnology in neurodegenerative diseases

J Jampílek, K Kráľová, P Novák, M Novák - Nanobiotechnology in …, 2019 - Springer
Abstract “Neurodegenerative disease” is a term for a variety of disorders that primarily affect
neurons in the human brain and spinal cord. These diseases are presently incurable and …

Interactions of the Aβ (1–42) Peptide with Boron Nitride Nanoparticles of Varying Curvature in an Aqueous Medium: Different Pathways to Inhibit β-Sheet Formation

N Sorout, A Chandra - The Journal of Physical Chemistry B, 2021 - ACS Publications
The aggregation of amyloid β (Aβ) peptide triggered by its conformational changes leads to
the commonly known neurodegenerative disease of Alzheimer's. It is believed that the …