Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

N-myristoylation is a crucial signaling and pathogenic modification process that confers
hydrophobicity to cytosolic proteins. Although different large-scale approaches have been …

Post-translational modifications regulate diverse activities of a colossal number of proteins.
For example, various types of lipids can be covalently linked to proteins enzymatically or non …

Background Recurrent pregnancy loss (RPL) refers to two or more spontaneous abortions
that occur consecutively with the same spouse. RPL severely affects human reproduction …

Sperm cells undergo maturation during their transit throughout the epididymis. This process
takes place in region-specific manner in which sperm are battered by proteins secreted by …

Since its development as a strategy to study biological systems, click chemistry has found its
widespread use as a chemical tool in the discovery of post-translationally modified (PTM) …

N-Myristoyltransferase (NMT) catalyzes the amide-linked addition of the myristoyl (C14: 0)
moiety to the amino-terminal glycine of substrate molecules. The upregulation of NMT in …

Résumé Sur onze familles actuellement connues, la phosphodiestérase 10 (PDE10) est une
des plus récemment découverte. Si elle est surtout exprimée dans le cerveau (striatum), où …