Capsid assembly modulators as antiviral agents against HBV: molecular mechanisms and clinical perspectives
Despite a preventive vaccine being available, more than 250 million people suffer from
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …
Novel therapeutic strategies for chronic hepatitis B
S Phillips, R Jagatia, S Chokshi - Virulence, 2022 - Taylor & Francis
The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with
many compounds in various stages of development. This review aims to provide a …
many compounds in various stages of development. This review aims to provide a …
[HTML][HTML] Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infection
MS Sulkowski, K Agarwal, X Ma, TT Nguyen… - Journal of …, 2022 - Elsevier
Background & Aims Nucleos (t) ide reverse transcriptase inhibitors do not completely
suppress HBV DNA in chronic HBV infection (cHBV). Vebicorvir (VBR) is an investigational …
suppress HBV DNA in chronic HBV infection (cHBV). Vebicorvir (VBR) is an investigational …
[HTML][HTML] Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infection
MF Yuen, K Agarwal, X Ma, TT Nguyen, ER Schiff… - Journal of …, 2022 - Elsevier
Background & Aims HBV nucleos (t) ide reverse transcriptase inhibitors (NrtIs) do not
completely suppress HBV replication. Previous reports indicate persistent viremia during NrtI …
completely suppress HBV replication. Previous reports indicate persistent viremia during NrtI …
Recent advances in hepatitis B treatment
GM Prifti, D Moianos, E Giannakopoulou, V Pardali… - Pharmaceuticals, 2021 - mdpi.com
Hepatitis B virus infection affects over 250 million chronic carriers, causing more than
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …
The hepatitis B virus nucleocapsid—dynamic compartment for infectious virus production and new antiviral target
M Niklasch, P Zimmermann, M Nassal - Biomedicines, 2021 - mdpi.com
Hepatitis B virus (HBV) is a small enveloped DNA virus which replicates its tiny 3.2 kb
genome by reverse transcription inside an icosahedral nucleocapsid, formed by a single …
genome by reverse transcription inside an icosahedral nucleocapsid, formed by a single …
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
H Vanrusselt, DB Kum, V Taverniti, C Liu… - Journal of …, 2023 - Am Soc Microbiol
Capsid assembly modulators (CAMs) are a novel class of therapeutic small molecules with
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
Current progress in the development of hepatitis B virus capsid assembly modulators: chemical structure, mode-of-action and efficacy
H Kim, C Ko, JY Lee, M Kim - Molecules, 2021 - mdpi.com
Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA
T Watanabe, S Hayashi, Y Zhaoyu, H Inada… - Journal of …, 2024 - Springer
Background Currently, standard treatments for chronic hepatitis B such as nucleos (t) ide
analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a …
analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a …
Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis
The core protein (Cp) of hepatitis B virus (HBV) assembles pregenomic RNA (pgRNA) and
viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA …
viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA …