An emerging theme of studies with spontaneous, engineered and induced mutant mice is
that phenotypes often depend on genetic background, implying that genetic modifiers have …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …

Birth defects (congenital anomalies) are the leading cause of death in babies under 1 year
of age. Neural tube defects (NTD), with a birth incidence of approximately 1/1000 in …

Defects in neural tube formation are among the most common malformations leading to
infant mortality. Although numerous genetic loci appear to contribute to the defects observed …

A survey of defined species of cell surface and extracellular matrix heparan sulfate
proteoglycans (HSPG) was performed in a search for cellular proteoglycans that can …

Hope Northrup, MD, and Kelly A. Volcik~ eural tube defects (NTDs) are the most common
severely disabling birth defects in the United States, with a frequency of approximately 1 of …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

Metastasis is one of the most important and complex processes in human neoplastic
disease. A large number of both positive and negative events must occur to permit a tumor …

Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by
folk acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to …