Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

Simple Summary Prostate cancer is the most common malignancy in men, with a high
mortality rate when disease progresses to metastasis and therapeutic resistance. Evidence …

Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and
proliferative activities in cancer cells. The binding of hexokinase 2 to the outer membrane of …

Docetaxel resistance remains one of the main problems in clinical treatment of metastatic
prostate cancer (PCa). Previous studies identified differently expressed lncRNAs in …

Purpose Several studies have reported that among patients with localized prostate cancer,
black men have a shorter overall survival (OS) time than white men, but few data exist for …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

Molecular characterization of radical prostatectomy specimens after systemic therapy may
identify a gene expression profile for resistance to therapy. This study assessed tumor cells …

Several mechanisms facilitate the progression of hormone-sensitive prostate cancer to
castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for …

Drug resistance of cancer cells is recognized as the primary cause of failure of
chemotherapeutic treatment in most human cancers. Growing evidences support the idea …

Background Bone metastasis is the leading cause of death in patients with prostate cancer
(PCa) and currently has no effective treatment. Disseminated tumor cells in bone marrow …