The anomalous pharmacology of fentanyl
E Kelly, K Sutcliffe, D Cavallo… - British journal of …, 2023 - Wiley Online Library
Fentanyl is a key therapeutic, used in anaesthesia and pain management. It is also
increasingly used illicitly and is responsible for a large and growing number of opioid …
increasingly used illicitly and is responsible for a large and growing number of opioid …
Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review
A Moustaqim-Barrette, D Dhillon, J Ng, K Sundvick… - BMC public health, 2021 - Springer
Background Opioid related overdoses and overdose deaths continue to constitute an urgent
public health crisis. The implementation of naloxone programs, such as 'take-home …
public health crisis. The implementation of naloxone programs, such as 'take-home …
Steep increases in fentanyl-related mortality west of the Mississippi River: recent evidence from county and state surveillance
Background Overdose deaths from synthetic opioids (eg, fentanyl) increased 10-fold in the
United States from 2013 to 2018, despite such opioids being rare in illicit drug markets west …
United States from 2013 to 2018, despite such opioids being rare in illicit drug markets west …
Shifting North American drug markets and challenges for the system of care
Drug markets are dynamic systems which change based on demand, competition,
legislation and revenue. Shifts that are not met with immediate and appropriate responses …
legislation and revenue. Shifts that are not met with immediate and appropriate responses …
Real-world study of multiple naloxone administration for opioid overdose reversal among bystanders
R Abdelal, A Raja Banerjee, S Carlberg-Racich… - Harm Reduction …, 2022 - Springer
Background The increasing prevalence of highly potent, illicitly manufactured fentanyl and
its analogues (IMF) in the USA is exacerbating the opioid epidemic which has worsened …
its analogues (IMF) in the USA is exacerbating the opioid epidemic which has worsened …
Adverse events related to bystander naloxone administration in cases of suspected opioid overdose in British Columbia: an observational study
A Moustaqim-Barrette, K Papamihali, S Williams… - PLoS …, 2021 - journals.plos.org
Introduction Take-Home Naloxone programs have been introduced across North America in
response to rising opioid overdose deaths. There is currently limited real-world data on …
response to rising opioid overdose deaths. There is currently limited real-world data on …
The need for multiple naloxone administrations for opioid overdose reversals: a review of the literature
R Abdelal, AR Banerjee, S Carlberg-Racich… - Substance …, 2022 - journals.sagepub.com
Background A growing challenge in the opioid epidemic is the rise of highly potent synthetic
opioids,(ie, illicitly manufactured fentanyl [IMF]) entering the US non-prescription opioid …
opioids,(ie, illicitly manufactured fentanyl [IMF]) entering the US non-prescription opioid …
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Abstract Naloxone is a World Health Organization (WHO)-listed essential medicine and is
the first choice for treating the respiratory depression of opioids, also by lay-people …
the first choice for treating the respiratory depression of opioids, also by lay-people …
Opioid overdose reversals using naloxone in New York City by people who use opioids: Implications for public health and overdose harm reduction approaches from …
S Parkin, J Neale, C Brown, ANC Campbell… - International Journal of …, 2020 - Elsevier
Background Adverse reactions to naloxone, such as withdrawal symptoms and aggression,
are widely recognised in the literature by pharmaceutical manufacturers and clinical …
are widely recognised in the literature by pharmaceutical manufacturers and clinical …
High-dose naloxone formulations are not as essential as we thought
PM Lemen, DP Garrett, E Thompson, M Aho… - Harm Reduction …, 2024 - Springer
Naloxone is an effective FDA-approved opioid antagonist for reversing opioid overdoses.
Naloxone is available to the public and can be administered through intramuscular (IM) …
Naloxone is available to the public and can be administered through intramuscular (IM) …