The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Background Macrophages are innate immune cells with diverse functional and molecular
phenotypes. This diversity is largely unexplored at the level of single-cell proteomes …

We introduce BacDrop, a highly scalable technology for bacterial single-cell RNA
sequencing that has overcome many challenges hindering the development of scRNA-seq …

Cell atlas projects and high-throughput perturbation screens require single-cell sequencing
at a scale that is challenging with current technology. To enable cost-effective single-cell …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

Liquid–liquid phase separation is a major mechanism of subcellular compartmentalization,.
Although the segregation of RNA into phase-separated condensates broadly affects RNA …

Abstract Single-cell RNA-Seq (scRNA-Seq) profiles gene expression of individual cells.
Recent scRNA-Seq datasets have incorporated unique molecular identifiers (UMIs). Using …