Synthesis, structure–activity relationship, and mechanism of a series of diarylhydrazide compounds as potential antifungal agents
R Liu, Z Li, S Liu, J Zheng, PP Zhu… - Journal of Agricultural …, 2023 - ACS Publications
A series of simple diarylhydrazide derivatives (45 examples) were well-designed, prepared,
and screened for their antifungal activities both in vitro and in vivo. Bioassay results …
and screened for their antifungal activities both in vitro and in vivo. Bioassay results …
Synthesis, Characterization, and Anti-Cancer Activity of Some New N′-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives
Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone derivatives
4a–h were synthesized and fully characterized by IR, NMR (1H-NMR and 13C-NMR) …
4a–h were synthesized and fully characterized by IR, NMR (1H-NMR and 13C-NMR) …
Carbonic anhydrase inhibition of Schiff base derivative of imino-methyl-naphthalen-2-ol: Synthesis, structure elucidation, molecular docking, dynamic simulation and …
In the present study, we have designed and synthesized a Schiff base derivative 3 and
characterized by FT-IR, 1 H and 13 C NMR spectroscopy. Single crystal X-ray diffraction and …
characterized by FT-IR, 1 H and 13 C NMR spectroscopy. Single crystal X-ray diffraction and …
AILDE Computer-Aided Discovery of Novel Ibuprofen–Coumarin Antitumor Lead Compounds Targeting Cyclooxygenase-2
F Wu, T Wang, X Tang, S Dong, L Luo, C Luo, J Ma… - ACS …, 2024 - ACS Publications
Starting from three ibuprofen–coumarin hit compounds, we designed 18 derivative
compounds targeting cyclooxygenase-2 (COX-2) by introducing different substituents onto …
compounds targeting cyclooxygenase-2 (COX-2) by introducing different substituents onto …
Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones
Some novel hydrazone derivatives 6a–o were synthesized from the key intermediate 4-
Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR …
Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR …
Design and evaluation of antimicrobial activity of new pyrazole, 1, 2, 4-triazole, and 1, 3, 4-thiadiazol derivatives bearing 1, 4-dihydroquinoxaline moiety
NAA Elkanzi, H Hrichi - Russian Journal of Bioorganic Chemistry, 2020 - Springer
An effective method for synthesizing a series of fifteen new compounds ethyl 3-(2-(3-amino-
1, 4-dihydroquinoxaline-2-carbonyl) hydrazono) butanoate (II), 3-amino-N'-benzylidene-1, 4 …
1, 4-dihydroquinoxaline-2-carbonyl) hydrazono) butanoate (II), 3-amino-N'-benzylidene-1, 4 …
Facile Syntheses and Molecular-Docking of Novel Substituted 3,4-Dimethyl-1H-pyrrole-2-carboxamide/carbohydrazide Analogues with Antimicrobial and Antifungal …
The article describes the use of facile one-pot, high-yielding reactions to synthesize
substituted 3, 4-dimethyl-1 H-pyrrole-2-carboxamides 3a–m and carbohydrazide analogues …
substituted 3, 4-dimethyl-1 H-pyrrole-2-carboxamides 3a–m and carbohydrazide analogues …
Carbonic Anhydrase Inhibitory Potential of 1, 2, 4-triazole-3-thione Derivatives of Flurbiprofen, Ibuprofen and 4-tert-butylbenzoic Hydrazide: Design, Synthesis …
Background: The over-expression of the carbonic anhydrases results in some specific
carcinomas including pancreatic, gastric and brain tumor. Tumors are distinguished under …
carcinomas including pancreatic, gastric and brain tumor. Tumors are distinguished under …
Quantum‐Chemical Studies to Approach the Antioxidant Mechanism of Nonphenolic Hydrazone Schiff Base Analogs: Synthesis, Molecular Structure, Hirshfeld and …
MS Alam, DU Lee - Bulletin of the Korean Chemical Society, 2015 - Wiley Online Library
In the present study, five nonphenolic (E)‐N′‐benzylidenebenzohydrazides including three
new compounds were synthesized and evaluated for their free radical scavenging activities …
new compounds were synthesized and evaluated for their free radical scavenging activities …
[PDF][PDF] Synthesis, anticonvulsant activity and cytotoxicity of novel valproic acid derivatives
TA Sheha, TS Ibrahim, NE Abo-Dya… - IOSR J. Appl …, 2017 - researchgate.net
Objective: The aim of this work was to construct novel hydrazones and thiosemsicarbazide
derivatives of valproic acid. The new targets will be evaluated for their anticonvulsant activity …
derivatives of valproic acid. The new targets will be evaluated for their anticonvulsant activity …