Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

Normal human breast epithelial cells show a high degree of phenotypic plasticity in
monolayer culture and express many traits that otherwise characterize tumor cells in vivo …

Abstract Introduction A subpopulation (CD44+/CD24-) of breast cancer cells has been
reported to have stem/progenitor cell properties. The aim of this study was to investigate …

Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life
mirror those of one of the most common cause of death—metastatic cancer. Epithelial to …

The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is
crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort
has been concentrated on understanding the processes of metastasis, how a primary …

Breast cancers often progress from a hormone-dependent, nonmetastatic, antiestrogen-
sensitive phenotype to a hormone-independent, antiestrogen-and chemotherapy-resistant …