Galectin-2 in health and diseases
MN Negedu, CA Duckworth, LG Yu - International Journal of Molecular …, 2022 - mdpi.com
Galectin-2 is a prototype member of the galactoside-binding galectin family. It is
predominately expressed in the gastrointestinal tract but is also detected in several other …
predominately expressed in the gastrointestinal tract but is also detected in several other …
A brief history of Charcot-Leyden crystal protein/galectin-10 research
J Su - Molecules, 2018 - mdpi.com
Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and
blood vessels. The significant presence of eosinophils in these tissues are associated with …
blood vessels. The significant presence of eosinophils in these tissues are associated with …
Soluble Human Lectins at the Host–Microbe Interface
AL Peiffer, AE Dugan… - Annual Review of …, 2024 - annualreviews.org
Human lectins are integral to maintaining microbial homeostasis on the skin, in the blood,
and at mucosal barriers. These proteins can recognize microbial glycans and inform the host …
and at mucosal barriers. These proteins can recognize microbial glycans and inform the host …
Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity
Y Si, Y Yao, GJ Ayala, X Li, Q Han, W Zhang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background The structure of human galectin-16 (Gal-16) has yet to be solved, and its
function has remained elusive. Methods X-ray crystallography was used to determine the …
function has remained elusive. Methods X-ray crystallography was used to determine the …
[HTML][HTML] Linker remodels human Galectin-8 structure and regulates its hemagglutination and pro-apoptotic activity
Y Si, J Cai, J Zhu, Y Wang, F Zhang, L Meng… - International Journal of …, 2023 - Elsevier
Numerous articles have reported the involvement of linker in regulating bioactivity of tandem-
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …
Galectins in host–pathogen interactions: structural, functional and evolutionary aspects
GR Vasta - Lectin in Host Defense Against Microbial Infections, 2020 - Springer
Galectins are a family of ß-galactoside-binding lectins characterized by a unique sequence
motif in the carbohydrate recognition domain, and evolutionary and structural conservation …
motif in the carbohydrate recognition domain, and evolutionary and structural conservation …
Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding
J Su, J Gao, Y Si, L Cui, C Song, Y Wang, R Wu… - …, 2018 - academic.oup.com
Abstract Galectin-10 (Gal-10) which forms Charcot-Leyden crystals in vivo, is crucial to
regulating lymph cell function. Here, we solved the crystal structures of Gal-10 and eight …
regulating lymph cell function. Here, we solved the crystal structures of Gal-10 and eight …
Structure–function studies of galectin‐14, an important effector molecule in embryology
Y Si, Y Li, T Yang, X Li, GJ Ayala, KH Mayo… - The FEBS …, 2021 - Wiley Online Library
The expression of prototype galectin‐14 (Gal‐14) in human placenta is higher than any
other galectin, suggesting that it may play a role in fetal development and regulation of …
other galectin, suggesting that it may play a role in fetal development and regulation of …
Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138
J Su, Y Wang, Y Si, J Gao, C Song, L Cui, R Wu… - Scientific reports, 2018 - nature.com
Abstract During pregnancy, placental protein-13 (galectin-13) is highly expressed in the
placenta and fetal tissue, and less so in maternal serum that is related to pre-eclampsia. To …
placenta and fetal tissue, and less so in maternal serum that is related to pre-eclampsia. To …
Modulation of the Gal-9/TIM-3 immune checkpoint with α-lactose. Does anomery of lactose matter?
Simple Summary The disaccharide lactose is a common excipient in pharmaceutical
products. In addition, the two anomers α-and β-lactose can exert immuno-modulatory effects …
products. In addition, the two anomers α-and β-lactose can exert immuno-modulatory effects …