Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …

Spinal cord injury (SCI) involves diverse injury responses in different cell types in a
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …

Gut dysbiosis contributes to Alzheimer's disease (AD) pathogenesis, and Bacteroides strains
are selectively elevated in AD gut microbiota. However, it remains unknown which …

Background: The development of thoracic aortic dissection (TAD) is closely related to
extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Astrocytes become reactive in response to insults to the central nervous system by adopting
context-specific cellular signatures and outputs, but a systematic understanding of the …

Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some
evidence suggests that misfolded protein aggregates found in AD brains may have …

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and
survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer's …