Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Aging can be seen as a physiological progression of biomolecular damage and the
accumulation of defective cellular components, which trigger and amplify the process …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the
second or third trimester of pregnancy. GDM can lead to short-term and long-term …

In the present study, we investigated a novel signaling target in diabetic cardiomyopathy
where inflammation induces caspase-1-dependent cell death, pyroptosis, involving Nek7 …

The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in
adults but also in children and adolescents. Diabetes is associated with macrovascular …

The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …

The incidence of heart failure (HF) continues to increase rapidly in patients with diabetes. It
is marked by myocardial remodeling, including fibrosis, hypertrophy, and cell death, leading …

Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Diabetic cardiomyopathy (DCM) is a prevalent cardiovascular complication of diabetes
mellitus, characterized by high morbidity and mortality rates worldwide. However, treatment …