Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …

Accumulating evidence suggests that spinal cord astrocytes play an important role in
neuropathic pain sensitization by releasing astrocytic mediators (eg cytokines, chemokines …

Licorice is an herbal plant named for its unique sweet flavor. It is widely used in the food and
tobacco industries as a sweetener. Licorice is also used in traditional Chinese medicine …

The emerging literature implicates a role for glia/cytokines in persistent pain. However, the
mechanisms by which these non-neural elements contribute to CNS activity-dependent …

Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …