Disorders of IGFs and IGF-1R signaling pathways

BE Forbes, AJ Blyth, JM Wit - Molecular and cellular endocrinology, 2020 - Elsevier
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …

Overview of statistical methods for genome-wide association studies (GWAS)

B Hayes - Genome-wide association studies and genomic …, 2013 - Springer
This chapter provides an overview of statistical methods for genome-wide association
studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by …

Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature

L Karim, H Takeda, LI Lin, T Druet, JAC Arias… - Nature …, 2011 - nature.com
We report mapping of a quantitative trait locus (QTL) with a major effect on bovine stature to
a∼ 780-kb interval using a Hidden Markov Model–based approach that simultaneously …

Facial genetics: a brief overview

S Richmond, LJ Howe, S Lewis, E Stergiakouli… - Frontiers in …, 2018 - frontiersin.org
Historically, craniofacial genetic research has understandably focused on identifying the
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …

Four loci explain 83% of size variation in the horse

S Makvandi-Nejad, GE Hoffman, JJ Allen, E Chu, E Gu… - PloS one, 2012 - journals.plos.org
Horse body size varies greatly due to intense selection within each breed. American
Miniatures are less than one meter tall at the withers while Shires and Percherons can …

[HTML][HTML] Accuracy of genomic predictions of residual feed intake and 250-day body weight in growing heifers using 625,000 single nucleotide polymorphism markers

JE Pryce, J Arias, PJ Bowman, SR Davis… - Journal of dairy …, 2012 - Elsevier
Feed makes up a large proportion of variable costs in dairying. For this reason, selection for
traits associated with feed conversion efficiency should lead to greater profitability of …

Derived variants at six genes explain nearly half of size reduction in dog breeds

M Rimbault, HC Beale, JJ Schoenebeck… - Genome …, 2013 - genome.cshlp.org
Selective breeding of dogs by humans has generated extraordinary diversity in body size. A
number of multibreed analyses have been undertaken to identify the genetic basis of this …

Polymorphic regions affecting human height also control stature in cattle

JE Pryce, BJ Hayes, S Bolormaa, ME Goddard - Genetics, 2011 - academic.oup.com
Orthologous positions of 55 genes associated with height in four human populations were
located on the bovine genome. Single nucleotide polymorphisms close to eight of these …

PLAG1 and NCAPG‐LCORL in livestock

A Takasuga - Animal Science Journal, 2016 - Wiley Online Library
A recent progress on stature genetics has revealed simple genetic architecture in livestock
animals in contrast to that in humans. PLAG1 and/or NCAPG‐LCORL, both of which are …

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

M He, M Xu, B Zhang, J Liang, P Chen… - Human molecular …, 2015 - academic.oup.com
Human height is associated with risk of multiple diseases and is profoundly determined by
an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large …