Disorders of IGFs and IGF-1R signaling pathways
BE Forbes, AJ Blyth, JM Wit - Molecular and cellular endocrinology, 2020 - Elsevier
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …
regulate multiple physiological processes, including mammalian development, metabolism …
Overview of statistical methods for genome-wide association studies (GWAS)
B Hayes - Genome-wide association studies and genomic …, 2013 - Springer
This chapter provides an overview of statistical methods for genome-wide association
studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by …
studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by …
Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
L Karim, H Takeda, LI Lin, T Druet, JAC Arias… - Nature …, 2011 - nature.com
We report mapping of a quantitative trait locus (QTL) with a major effect on bovine stature to
a∼ 780-kb interval using a Hidden Markov Model–based approach that simultaneously …
a∼ 780-kb interval using a Hidden Markov Model–based approach that simultaneously …
Facial genetics: a brief overview
Historically, craniofacial genetic research has understandably focused on identifying the
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …
Four loci explain 83% of size variation in the horse
S Makvandi-Nejad, GE Hoffman, JJ Allen, E Chu, E Gu… - PloS one, 2012 - journals.plos.org
Horse body size varies greatly due to intense selection within each breed. American
Miniatures are less than one meter tall at the withers while Shires and Percherons can …
Miniatures are less than one meter tall at the withers while Shires and Percherons can …
[HTML][HTML] Accuracy of genomic predictions of residual feed intake and 250-day body weight in growing heifers using 625,000 single nucleotide polymorphism markers
Feed makes up a large proportion of variable costs in dairying. For this reason, selection for
traits associated with feed conversion efficiency should lead to greater profitability of …
traits associated with feed conversion efficiency should lead to greater profitability of …
Derived variants at six genes explain nearly half of size reduction in dog breeds
M Rimbault, HC Beale, JJ Schoenebeck… - Genome …, 2013 - genome.cshlp.org
Selective breeding of dogs by humans has generated extraordinary diversity in body size. A
number of multibreed analyses have been undertaken to identify the genetic basis of this …
number of multibreed analyses have been undertaken to identify the genetic basis of this …
Polymorphic regions affecting human height also control stature in cattle
Orthologous positions of 55 genes associated with height in four human populations were
located on the bovine genome. Single nucleotide polymorphisms close to eight of these …
located on the bovine genome. Single nucleotide polymorphisms close to eight of these …
PLAG1 and NCAPG‐LCORL in livestock
A Takasuga - Animal Science Journal, 2016 - Wiley Online Library
A recent progress on stature genetics has revealed simple genetic architecture in livestock
animals in contrast to that in humans. PLAG1 and/or NCAPG‐LCORL, both of which are …
animals in contrast to that in humans. PLAG1 and/or NCAPG‐LCORL, both of which are …
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
Human height is associated with risk of multiple diseases and is profoundly determined by
an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large …
an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large …