As nanometer-scale portals in biological membranes, protein ionic channels act as
gatekeepers, controlling the traffic of ions and macromolecules into and out of cells …

Regulation of mitochondrial outer membrane (MOM) permeability has dual importance: in
normal metabolite and energy exchange between mitochondria and cytoplasm, and thus in …

Highlights•Nanopore offers single molecule detection with high specificity and
sensitivity.•Protein pores have emerged as a versatile platform for single molecule …

Clostridial binary toxins (Clostridium perfringens Iota toxin, Clostridium difficile transferase,
Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins …

To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane
traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides …

Proteins are critical to cellular function and survival. They are complex molecules with
precise structures and chemistries, which allow them to serve diverse functions for …

Protective antigen channel is the central component of the deadly anthrax exotoxin
responsible for binding and delivery of the toxin's enzymatic lethal and edema factor …

Pore-forming toxins are an important group of natural molecules that damage cellular
membranes by forming transmembrane pores. They are used by many organisms for attack …

Introduction: Present-day rational drug design approaches are based on exploiting unique
features of the target biomolecules, small-or macromolecule drug candidates and physical …

Bacteria secrete and harbor in their membranes a number of pore-forming proteins. Some of
these are bona fide ion channels that may respond to changes in membrane tension …