The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …

Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a
neoplastic disorder owing to the discovery of recurrent activating MAPK (RAS-RAF-MEK …

Background Selpercatinib is a first-in-class, highly selective RET kinase inhibitor with CNS
activity that has shown efficacy in RET fusion-positive lung and thyroid cancers. RET fusions …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Context Rosai-Dorfman disease is an uncommon histiocytic disorder most frequently
presenting as bilateral cervical lymphadenopathy in children and young adults. Extranodal …

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in
3 infants with multisystemic disease involving the liver and hematopoietic system. This entity …

Abstract ABSTRACT: Colony-Stimulating Factor-1 Receptor (CSF1R) is a receptor tyrosine
kinase that controls the differentiation and maintenance of most tissue-resident …