Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense
infection and tissue stress, sample and present antigen to T lymphocytes, and induce …

T‐cell development is a highly coordinated process that depends on interactions between
thymocytes, thymic epithelium, and bone marrow (BM)‐derived dendritic cells (DCs). Before …

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various
tissues including the thymus and has structural homology with a number of cell-surface …

Efficient generation of regulatory T cells (Treg cells) in the thymus requires CD28
costimulation, but it is not known why. Here, molecular mapping of CD28 costimulation …

It is well established that lymphoid dendritic cells (DC) play an important role in the immune
system. Beside their role as potent inducers of primary T cell responses, DC seem to play a …

Frank Barlow's magisterial biography, first published in 1970 and now reissued with new
material, rescues Edward the Confessor from contemporary myth and subsequent bogus …

CD4+ 25+ T cells are a unique population of immunoregulatory T cells which are critical for
the prevention of autoimmunity. To address the thymic selection of these cells we have used …

During development in the thymus, T cells are rendered tolerant to self antigens. It is now
apparent that thymocytes bearing self-reactive T cell receptors can be tolerized by …

The epithelial component of the thymic microenvironment is indispensable for the
generation of T lymphocytes. Although the heterogeneity of this epithelium is well …

Publisher Summary This chapter summarizes the role of CD4 and CD8 in both T cell
activation and differentiation. CD4 and CD8 are cell surface glycoproteins expressed on T …