[HTML][HTML] Recommended treatment for antibody-mediated rejection after kidney transplantation: the 2019 expert consensus from the transplantion society working …

CA Schinstock, RB Mannon, K Budde, AS Chong… - …, 2020 - journals.lww.com
This meeting was organized by The Transplantation Society with the assistance of an
unconditional education grant from CSL Behring. CSL Behring had no involvement in the …

The therapeutic challenge of late antibody‐mediated kidney allograft rejection

GA Böhmig, F Eskandary, K Doberer… - Transplant …, 2019 - Wiley Online Library
Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …

[HTML][HTML] Assessment of tocilizumab (anti–interleukin-6 receptor monoclonal) as a potential treatment for chronic antibody-mediated rejection and transplant …

J Choi, O Aubert, A Vo, A Loupy, M Haas… - American Journal of …, 2017 - Elsevier
Extending the functional integrity of renal allografts is the primary goal of transplant
medicine. The development of donor-specific antibodies (DSAs) posttransplantation leads to …

[HTML][HTML] Treatment of chronic antibody mediated rejection with intravenous immunoglobulins and rituximab: a multicenter, prospective, randomized, double-blind …

F Moreso, M Crespo, JC Ruiz, A Torres… - American Journal of …, 2018 - Elsevier
There are no approved treatments for chronic antibody mediated rejection (ABMR). We
conducted a multicenter, prospective, randomized, placebo-controlled, double-blind clinical …

[HTML][HTML] Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization …

WH Marks, N Mamode, RA Montgomery… - American Journal of …, 2019 - Elsevier
We report results of a phase 2, randomized, multicenter, open-label, two-arm study
evaluating the safety and efficacy of eculizumab in preventing acute antibody-mediated …

Subclinical antibody-mediated rejection after kidney transplantation: treatment outcomes

S Parajuli, E Joachim, S Alagusundaramoorthy… - …, 2019 - journals.lww.com
Background. Antibody-mediated rejection (AMR) is a leading cause of morbidity and
mortality after kidney transplantation. Early diagnosis and treatment of subclinical AMR …

Early effects of first‐line treatment with anti‐interleukin‐6 receptor antibody tocilizumab for chronic active antibody‐mediated rejection in kidney transplantation

A Lavacca, R Presta, C Gai, A Mella… - Clinical …, 2020 - Wiley Online Library
Introduction Chronic active antibody‐mediated rejection (cAMR) is a major determinant of
late allograft failure. Rituximab/immunoglobulins (IVIg)+ plasma exchange (PLEX) showed …

Clazakizumab for the treatment of chronic active antibody-mediated rejection (AMR) in kidney transplant recipients: phase 3 IMAGINE study rationale and design

PW Nickerson, GA Böhmig, S Chadban, D Kumar… - Trials, 2022 - Springer
Background Chronic active antibody-mediated rejection (AMR) is a major cause of graft loss
with no approved drugs for its treatment. Currently, off-label regimens are used, reflecting …

Antibody-mediated rejection: a review

JC Garces, S Giusti, C Staffeld-Coit… - Ochsner …, 2017 - ochsnerjournal.org
Background: Chronic antibody injury is a serious threat to allograft outcomes and is
therefore the center of active research. In the continuum of allograft rejection, the …

A systematic review of the use of rituximab for the treatment of antibody-mediated renal transplant rejection

PS Macklin, PJ Morris, SR Knight - Transplantation Reviews, 2017 - Elsevier
Rituximab is a B-lymphocyte depleting agent that is used to treat hematological
malignancies and autoimmune diseases. Recently, it has gained interest as an …