Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

Guanosine (GUO) is an endogenous modulator of glutamatergic excitotoxicity and has been
shown to promote neuroprotection in in vivo and in vitro models of neurotoxicity. This study …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine, a guanine-based purine, is an extracellular signaling molecule that is released
from astrocytes and has been shown to promote central nervous system defenses in several …

Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …

Stroke is the major cause of death and the most frequent cause of disability in the adult
population worldwide. Guanosine plays an important neuroprotective role in several …

Guanosine, a guanine‐based purine, is an extracellular signaling molecule that is released
from astrocytes and shows neuroprotective effects in several in vivo and in vitro studies. Our …

Background and Purpose Stroke is a devastating disease. Both excitotoxicity and oxidative
stress play important roles in ischemic brain injury, along with harmful impacts on ischemic …