Molecular mechanisms driving progression of liver cirrhosis towards hepatocellular carcinoma in chronic hepatitis B and C infections: a review

T Kanda, T Goto, Y Hirotsu, M Moriyama… - International journal of …, 2019 - mdpi.com
Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

Aging and liver disease

IH Kim, T Kisseleva, DA Brenner - Current opinion in …, 2015 - journals.lww.com
Treatment of older patients with liver disease may require different or longer interventions.
Transplantation of an older liver will be less tolerant of subsequent injury. Future studies are …

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

HB El–Serag, KL Rudolph - Gastroenterology, 2007 - Elsevier
Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …

[PDF][PDF] Liver biopsy

DC Rockey, SH Caldwell, ZD Goodman… - …, 2009 - Wiley Online Library
Histological assessment of the liver, and thus, liver biopsy, is a cornerstone in the evaluation
and management of patients with liver disease and has long been considered to be an …

[PDF][PDF] HCV genotype 3 is associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of US Veterans with HCV

F Kanwal, JR Kramer, J Ilyas, Z Duan… - Hepatology, 2014 - Wiley Online Library
Data show that viral genotype 1 may increase the risk of cirrhosis and hepatocellular
carcinoma (HCC) compared to genotype 2 in patients with chronic hepatitis C virus (HCV) …

[HTML][HTML] PNPLA3 I148M polymorphism and progressive liver disease

P Dongiovanni, B Donati, R Fares… - World journal of …, 2013 - ncbi.nlm.nih.gov
Abstract The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like
phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is …

Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data

G Leandro, A Mangia, J Hui, P Fabris, L Rubbia–Brandt… - Gastroenterology, 2006 - Elsevier
Background & Aims: Steatosis is a frequent histologic finding in chronic hepatitis C (CHC),
but it is unclear whether steatosis is an independent predictor for liver fibrosis. We evaluated …

Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease

A Lonardo, LE Adinolfi, P Loria, N Carulli, G Ruggiero… - Gastroenterology, 2004 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) and hepatitis C virus (HCV)-related liver disease
are common in the general population, but their concurrence is 2-to 3-fold higher than would …

Steatosis in chronic hepatitis C: why does it really matter?

T Asselah, L Rubbia-Brandt, P Marcellin, F Negro - Gut, 2006 - gut.bmj.com
Hepatic steatosis is a common histological feature of chronic hepatitis C. Various factors are
associated with hepatic steatosis, including obesity, high alcohol consumption, diabetes …

The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis

B Palmentieri, I De Sio, V La Mura, M Masarone… - Digestive and Liver …, 2006 - Elsevier
AIM: The observation of bright liver echo pattern on ultrasound is commonly considered a
sign of hepatic steatosis. However, the interference of liver fibrosis on sensitivity and …