Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

The aim of evidence-based medicine is to improve the quality of health care by integrating
the best research evidence with clinical expertise and patient values. Evidence-based …

Introduction The risk of oesophageal adenocarcinoma (OAC) in non-dysplastic Barrett9s
oesophagus (BO) may have been overestimated. The objective was to estimate the …

Background Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is
associated with an increased risk of esophageal adenocarcinoma. We assessed whether …

Objective Reported malignant progression rates for low-grade dysplasia (LGD) in Barrett's
oesophagus (BO) vary widely. Expert histological review of LGD is advised, but limited data …

Barrett's esophagus (BE) is a condition in which the typical squamous epithelium of the
esophageal mucosa is replaced with columnar intestinal epithelium. 1, 2 BE is a known …

BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) is increasingly common among
patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations …

OBJECTIVES: Published data on the natural history of low-grade dysplasia (LGD) in
Barrett's esophagus (BE) are inconsistent and difficult to interpret. We investigated the …

Objective: Endoscopic therapy is increasingly being used in the treatment of high-grade
intraepithelial neoplasia (HGIN) and mucosal adenocarcinoma (BC) in patients with Barrett's …

Background The natural history of low-grade dysplasia (LGD) in patients with Barrett's
esophagus (BE) is unclear. Objective We performed a systematic review and meta-analysis …