The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Infant pain is a clinical reality. Effective pain management in infants requires a specialist
approach—analgesic protocols that have been designed for older children cannot simply be …

Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of
spinal inhibition in endogenous pain control. While the Gate Control Theory was based on …

Pain in early life can enhance the response to subsequent injury, but effects are influenced
by both the nature and timing of neonatal injury. Using plantar hindpaw incision, we …

We investigated how the biodistribution of cannabidiol (CBD) within the central nervous
system (CNS) is influenced by two different formulations, an oil-in-water (O/W) …

Neuraxial drugs provide robust pain control, have the potential to improve outcomes, and
are an important component of the perioperative care of children. Opioids or clonidine …

Brainstem–spinal cord connections play an essential role in adult pain processing, and the
modulation of spinal pain network excitability by brainstem nuclei is known to contribute to …

The descending pain modulatory system (DPMS) constitutes a network of widely distributed
brain regions whose integrated function is essential for effective modulation of sensory input …

The nociceptive network, responsible for transmission of nociceptive signals that generate
the pain experience, is not fully developed at birth. Descending serotonergic modulation of …

The mechanisms underlying the transition from acute nociceptive pain to centrally
maintained chronic pain are not clear. We have studied the contributions of the peripheral …