Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an
affordable and practical approach for heart valve replacement; therefore, it is attractive for …

Advances in material science and innovative medical technologies have allowed the
development of less invasive interventional procedures for deploying implant devices …

In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …

In situ heart valve tissue engineering is an emerging approach in which resorbable, off-the-
shelf available scaffolds are used to induce endogenous heart valve restoration. Such …

Pediatric heart valve disease affects children worldwide and necessitates valve
replacements that remodel and grow with the patient. Current valve manufacturing …

The concept of tissue engineering evolved long before the phrase was forged, driven by the
thromboembolic complications associated with the early total artificial heart programs of the …

Tissue-engineered heart valves (TEHVs) are emerging alternatives to current valve
prostheses and prospectively a lifelong replacement. Calcification, a pathological …

In situ heart valve tissue engineering approaches have been proposed as promising
strategies to overcome the limitations of current heart valve replacements. Tissue …