Skeletal muscle has a robust capacity for regeneration following injury. However, few if any
effective therapeutic options for volumetric muscle loss are available. Autologous muscle …

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects
and osteoarthritic lesions, consequently advances in innovative therapeutics are required …

A role for fibroblasts in physiological and pathological angiogenesis is now well recognized;
however, the precise mechanisms underlying their action have not been determined. Using …

With the identification of mesenchymal stem cells (MSCs) as pericytes, the details of bone
formation, regeneration, and repair take on new meaning. Growth factors and other …

The prognosis of patients with malignant glioma is extremely poor, despite the extensive
surgical treatment that they receive and recent improvements in adjuvant radio-and …

Angiogenesis is a multistep process of critical importance both in development and in
physiological and pathophysiological processes in the adult. It involves endothelial cell (EC) …

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-
inflammatory to reparative responses, and the cardiac fibroblast is a central player during …

Mesenchymal stem cells (MSCs) give origin to the marrow stromal environment that
supports hematopoiesis. These cells present a wide range of differentiation potentials and a …

Angiogenesis is the formation of new blood vessels from the existing vasculature. It is a
multistage process in which activated endothelial cells (EC) degrade basement membrane …

We developed human mesenchymal stem cell (MSC) lines that could differentiate into
various tissue cells including bone, neural cells, bone marrow (BM) stromal cells supporting …