Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Catalyst-free synthesis of imidazo [5, 1-b] quinazolines and their antimicrobial activity
PJ Patel, RM Vala, SG Patel, DB Upadhyay… - Journal of Molecular …, 2023 - Elsevier
Abstract In this study, imidazo [5, 1-b] quinazoline derivatives 4 (a–t) were synthesized via a
three-component reaction of 5-aminoimidazole-4-carbonitrile, 1, 3-cyclohexanedione …
three-component reaction of 5-aminoimidazole-4-carbonitrile, 1, 3-cyclohexanedione …
Quinazolin-4-one: A varsatile molecule
RD Amrutkar, SV Amrutkar… - Current Bioactive …, 2020 - ingentaconnect.com
Background: Quinazolines and quinazolinones constitute a major class of biologically active
molecules both from natural and synthetic sources. We will limit this review to compounds …
molecules both from natural and synthetic sources. We will limit this review to compounds …
A convenient one-pot synthesis of novel benzo [g] benzo [4, 5] imidazo [2, 1-b] quinazolines through Knoevenagel/Michael/Cyclization cascade reaction
M Ahmadusefi-Sarhadi, H Mehrabi, F Alizadeh-Bami… - Tetrahedron …, 2024 - Elsevier
A cost‐effective protocol has been used for the synthesis of novel benzo [g] benzo [4, 5]
imidazo [2, 1-b] quinazoline derivatives. This domino, one‐pot, three‐component reaction …
imidazo [2, 1-b] quinazoline derivatives. This domino, one‐pot, three‐component reaction …
Synthesis and characterization of Schiff bases derived from 3-aryl-2-formyl-4 (3H)-quinazolinone
Condensation of 3-aryl-4 (3H)-quinazolinone-2-carbaldehydes with different substituted
aniline under reflux conditions afforded a series of Schiff bases (imines) containing …
aniline under reflux conditions afforded a series of Schiff bases (imines) containing …
Quinazolinone: Pharmacophore with Endless Pharmacological Actions
Due to its extensive applications in the field of pharmaceutical chemistry and its potent
biological and pharmacological activities, including analgesic, antioxidant, antimicrobial …
biological and pharmacological activities, including analgesic, antioxidant, antimicrobial …
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1, 3-benzodioxol-5-yloxy)-N'-[substituted] …
P Kumar, L Tripathi - Medicinal Chemistry, 2021 - ingentaconnect.com
Background: About 50 million epileptic cases worldwide and 12 million in India are reported.
Currently, available drugs yield adequate control of seizure in 60-70% of patients and show …
Currently, available drugs yield adequate control of seizure in 60-70% of patients and show …