Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Wound healing requires a fine balance between the positive and deleterious effects of
reactive oxygen species (ROS); a group of extremely potent molecules, rate limiting in …

The self–non-self theory has dominated immunology since the 1950s. In the 1990s,
Matzinger and her colleagues suggested a new, competing theory, called the “danger …

Extracellular cell stress proteins are highly conserved phylogenetically and have been
shown to act as powerful signalling agonists and receptors for selected ligands in several …

Pathogen-and damage-associated molecular patterns are sensed by the immune system's
pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In …

Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

The neuroinflammatory hypothesis of Alzheimer's disease (AD) was proposed more than 30
years ago. The involvement of the two main types of glial cells microglia and astrocytes, in …

The complement system represents one of the evolutionary oldest arms of our immune
system and is commonly recognized as a liver‐derived and serum‐active system critical for …