The presence of heterocyclic moieties in all kinds of organic compounds of interest in
biology, pharmacology, optics, electronics, material sciences, and so on is sufficiently known …

Many excellent and up to date reviews on kinase inhibitors exist, and this area certainly
does not meet the normal criteria for a Chemical Reviews article. However, most of these …

Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

Inhibitors for tyrosine-specific protein kinases ultimately may constitute a novel family of
medicinally active agents. Unfortunately, the challenges associated with the acquisition of …

In the last 5 years, through combinatorial chemistry, high-throughput screening,
computational chemistry, and traditional medicinal chemistry, numerous inhibitors for …

The signaling for activation of protein tyrosine kinases (PTKs) is usually started by binding of
ligands to cell-surface receptors. However, recent evidence suggests the presence of ligand …

The multifactorial mechanistic nature of cancer calls for the development of multifunctional
therapeutic tools, ie, single compounds able to interact with multiple altered pathogenetic …

The word indole is derived from the word India: indigo (3), the blue dye, was first exported
from India to Europe in the 16th century. Indoles are generally crystalline colorless solids …

Protein tyrosine kinases (PTKs) play a crucial role in many cell regulatory processes. It is
therefore not surprising to see that functional perturbation of PTKs results in many diseases …

An efficient and economical method was developed for the synthesis of 3-substituted indoles
by one-pot three-component coupling reaction of a substituted or unsubstituted …