Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Cancer progression is a highly balanced process and is maintained by a sequence of finely
tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that …

Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including
the unfolded protein response (UPR) and autophagy, and induces programmed cell death …

The role of NOD-like receptor protein 3 (NLRP3)-mediated macrophages pyroptosis in acute
lung injury (ALI) is well-established. Quercetin (Que) is a natural bioflavonoid compound …

Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …

Lysosomes are key cellular organelles that metabolize extra-and intracellular substrates.
Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and …

Alternations of redox metabolism have been associated with the extension of lifespan in
roundworm Caenorhabditis elegans, caused by moderate mitochondrial dysfunction …

Caenorhabditis elegans (C. elegans) is a powerful model organism which has been
extensively characterized at the genetic and cellular levels and used to study various …