The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …

Objective Despite several clinicopathological factors being integrated as prognostic
biomarkers, the individual variants and risk stratification have not been fully elucidated in …

Transendothelial migration (TEM) of Th1 and Th17 cells across the blood–brain barrier
(BBB) has a critical role in the development of experimental autoimmune encephalomyelitis …

Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and
most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the …

OBJECT There are few and conflicting reports on the effects of delayed initiation of
chemoradiotherapy on the survival of patients with glioblastoma. The standard of care for …

Metastasis is the most lethal stage of cancer progression. The present study aimed to
investigate the underlying molecular mechanisms of melanoma metastasis using …

Development of high-throughput monitoring technologies enables interrogation of cancer
samples at various levels of cellular activity. Capitalizing on these developments, various …

Purpose: Cellular immunotherapies are currently being explored to eliminate highly invasive
and chemoradioresistant glioblastoma (GBM) cells involved in rapid relapse. We recently …

Glioblastoma multiforme (GBM) is the most common and aggressive adult primary brain
cancer, with< 10% of patients surviving for more than 3 years. Demographic and clinical …

Because of their ability to infiltrate normal brain tissue, gliomas frequently evade microscopic
surgical excision. The histologic infiltrative property of human glioma has been previously …